It would be great to have some artifact weapons and armor with unique features for a higher level Lootbox crawler.
I admire the Scimitar of the Vampire with its draining ability - melee has become much easier at early levels once I got it. But it is not useful at higher levels of the dungeon, cannot hit any enemy despite Melee skill maxed out.
Setting up some side quests to get some higher level melee artifacts may be a nice idea - so that you could complete the main story without completion of these quests, but they would allow for a different game play along the way.